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CLINICAL REPORTS ON TOPICAINE- Topical Anesthetic Gel

"Premedication to Reduce Discomfort during Screening Mammography "

July, 2008 The journal Radiology published the results of a clinical trial conducted by Colleen Lambertz, MSN, MBA, FNP; Christopher Johnson, MPH, Paul Montgomery MD, and James Maxwell MD. This was an independent, double blind, placebo controlled study on 418 women. The conclusion of this study was that premedication with 4% lidocaine gel (TOPICAINE®) significantly reduced discomfort during screening mammography, and reduced discomfort may improve the likelihood of future mammographic screening and early detection of breast cancer.
NOTE: Application of any topical anesthetic prior to mammography is an off-label use of the product. Only physicians and nurse practitioners can use medicinal products for off-label uses.

Read the abstract of the article.

"Topical Triple-Anesthetic Gel Compared With 3 Topical Anesthetics"

April, 2003 Cosmetic Dermatoloy magazine published a study by Dr Min-Wei Christine Lee, who evaluated the efficacy of 3 leading brands of topical anesthetics: TOPICAINE 4%, Ela-Max 5% (now LMX-5) and EMLA, and compared it to a compounded triple anesthetic "BLT". The study was done in 30 patients and the anesthetics and placebo control were randomly applied to different sites in the arm of the patients.
NOTE: In this study, the product was tested under occlusion. ESBA LABORATORIES DOES NOT RECOMMEND OCCLUSION.

Reprints of this study are available upon request.

"Chemical Peels Cure Darker Skin"

August, 2002 Dermatology Times magazine published an article describing the work of Dr Harold Pierce, an innovative Philadelphia dermatologist that uses TOPICAINE® 4% prior to chemical peels and wound debridement.
NOTE: Chemical peels and wound debridement are off-label uses of the product. Only physicians and nurse practitioners can use medicinal products for off-label uses.

Reprints of this study are available upon request.

"Topical Anesthetics: EMLA and Beyond"

December, 2001 Dermatologic Surgery magazine published a review article on seven anesthetics including TOPICAINE, EMLA, Ela-Max, S-Peel and others; authored by Dr Paul Friedman; Dr Erick Mafong, Edward Friedman BS and Dr Roy Geronimus.
NOTE: In this study, the product was tested under occlussion. ESBA LABORATORIES DOES NOT RECOMMEND OCCLUSION.

Reprints of this study are available upon request.

"Newer Anesthetics Block Nd-Yag Pain"

April, 2001 Cosmetic Surgery Times magazine published an interview with Dr Joshua Fogelman, principal investigator in a double-blind, placebo-controlled clinical trial on 24 patients comparing the efficacy of TOPICAINE® 4%, Ela-Max 5% (now named LMX-5) and EMLA. TOPICAINE® 4% showed the best efficacy overall.
NOTE: In this study, the product was tested under occlusion. ESBA LABORATORIES DOES NOT RECOMMEND OCCLUSION.

Reprints of this study are available upon request.

"30 Minute Topical Application Blocks Nd-Yag Pain"

July, 2000 Cosmetic Surgery Times magazine published an interview with Dr Paul M. Friedman, one of the investigators in a double-blind, placebo-controlled clinical trial in 24 patients comparing the efficacy of TOPICAINE® 4%, Ela-Max 5% and EMLA. TOPICAINE® 4% showed the best efficacy overall.
NOTE: In this study, the product was tested under occlusion. ESBA LABORATORIES DOES NOT RECOMMEND OCCLUSION.

Reprints of this study are available upon request.